Category: Research

Preliminary clinical data for glioblastoma multiforme patients enrolled in a Phase 1 clinical trial at the University of Alabama at Birmingham demonstrated that 92 percent of evaluable patients treated with INB-200 exceeded a median progression-free survival of seven months with concomitant temozolomide chemotherapy.

Over the past decade, the University of Alabama at Birmingham has become a national leader in clinical trials — studies examining the use of new treatments in people. And more patients than ever in Alabama have access to life-changing therapies at UAB.

A nationwide study of 196 cities shows that housing discrimination from 90 years ago still casts a historical shadow of inequities in colon cancer care today, S.M. Qasim Hussaini, M.D., of the University of Alabama at Birmingham and colleagues at the American Cancer Society and Johns Hopkins School of Public Health report in the journal JCO Oncology Practice.

Mark your calendars for this year's State of the Science Summit: Hematologic Malignancies coming to Birmingham on May 23, 2024.

The University of Alabama at Birmingham’s Isabel Scarinci, Ph.D., vice chair for Global and Rural Health in the Department of Obstetrics and Gynecology, was chosen to lead a workgroup charged with creating the United States cervical cancer elimination plan.  

When members of the O’Neal Comprehensive Cancer Center investigate complex questions together, the new therapies, discoveries and patient care improvements that result become more than the sum of the parts

The O’Neal Comprehensive Cancer Center at UAB is pleased to announce that the Breast Cancer Research Foundation of Alabama (BCRFA) has generously funded three Pre-R01 grants through the fall cycle of O’Neal Invests.

The advisory board of the O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham will host its 39th annual ArtBLINK Gala on Saturday, Feb. 3, at 6:30 p.m. in the UAB Kirklin Clinic.

The O’Neal Comprehensive Cancer Center at UAB is pleased to announce its fall 2023 O’Neal Invests grant awards.

UAB’s Breast Cancer Team presented at the San Antonio Breast Cancer Symposium (SABCS) December 5 through December 9, 2023.

UAB cancer biology undergraduate student Emma Hendrix attended the ASCO Quality Care Symposium October 27, 2023, to present her research poster “Evaluating shared-decision making among women with metastatic breast cancer.” One detail made this opportunity uniquely special however: She presented her research with her grandfather, oncologist Patrick Daugherty, M.D., in attendance.

Immunotherapy is a common type of treatment that uses the patient’s own immune system to fight cancer and other diseases. Gynecologic cancers are treated in different ways, but immunotherapy is becoming more common in treating cervical cancer, uterine (endometrial) cancer, and other cancers that start in women’s reproductive organs.

The O’Neal Comprehensive Cancer Center wants to thank everyone for their support and participation during October’s Breast Cancer Awareness Month. From Witches Rides to 5K runs, below are some photos highlighting events from around the greater Birmingham area.

The O’Neal Comprehensive Cancer Center is recruiting women in Alabama to join the WISDOM study, or Women Informed to Screen Depending On Measures of risk, which is an innovative national research study designed to test a personalized approach to breast cancer screening and prevention.

The O’Neal Comprehensive Cancer Center at UAB hosted its 23rd annual Research Retreat Friday, October 13, at Regions Field. More than 350 attendees joined the day-long event.

The O’Neal Comprehensive Cancer Center at UAB is pleased to announce its latest O’Neal Invests grant awards. O’Neal Invests funds UAB investigators initiating new cancer-related projects to do key preliminary work to enable competitive extramural applications. Applications for the seventh grant cycle were submitted in Spring 2023.

The O’Neal Comprehensive Cancer Center at UAB is pleased to announce that the Mike Slive Foundation has generously funded a Pre-R01 grant through the spring cycle of O’Neal Invests.

The O’Neal Comprehensive Cancer Center at UAB is pleased to announce that the Breast Cancer Resesarch Foundation of Alabama (BCRFA) has generously funded a Pre-R01 grant through the spring cycle of O’Neal Invests.

Birmingham’s Pepper Place has a striking new addition to its teeming farmers’ market and noted food offerings — a multimillion-dollar cancer research laboratory. 

A full course of radiation therapy in milliseconds rather than weeks: That’s the promise of flash therapy.

Alabama is one of three states currently offering an ovarian cancer car tag — and it is changing the future of ovarian cancer research. Since the tag’s inception, proceeds from each ovarian cancer car tag purchased have gone directly to the University of Alabama at Birmingham’s Division of Gynecologic Oncology to support ovarian cancer research.

UAB was well represented at one of the signature oncology conferences this year, ASCO, held in Chicago, Illinois, from May 31–June 4.

Markus Bredel, M.D., Ph.D., is lead author on “Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas” in Cell Reports Medicine (2023). This groundbreaking discovery not only marks a significant milestone in our understanding of diffuse gliomas but also paves the way for improved predictions of disease outcomes and the development of targeted treatment approaches.

The O’Neal Comprehensive Cancer Center at UAB recently awarded six projects a total of $530,000 in research grants through O'Neal Invests. The O’Neal Invests program funds UAB investigators initiating new cancer-related projects to do key, preliminary work in order to enable competitive R01 applications.